Amitriptilina

Antidepressivo tricíclico. Inibe recaptação de noradrenalina e serotonina.

1 de fev. de 20261 de

1 cite1×

Gestação:Categoria CRisco não pode ser descartado, usar se benefício justificar

INDICAÇÕES

Adultos

10-25mg à noite, aumentar gradualmente

1x/dia à noite

IMAOGRAVE

Crise hipertensiva

⛔ Intervalo de 14 dias

Outros anticolinérgicosGRAVE

Potencialização

⛔ Monitorar

{"compativel":true,"observacao":"Compatível, preferir ISRS"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1, 1/2, 2/2	-Normal drug metabolism -Standard dosing appropriate
Poor Metabolizer	4/4, 4/5, 5/5	-Reduced drug metabolism -Increased drug levels and toxicity risk -Consider dose reduction or alternative drug
Intermediate Metabolizer	1/4, 2/4	-Moderately reduced metabolism -May need dose adjustment
Ultra-rapid Metabolizer	1/1xN, 2/2xN	-Rapid drug metabolism -Reduced drug efficacy -May need increased dose or alternative drug