Azatioprina

Pró-droga de 6-mercaptopurina; inibe síntese de purinas

1 de fev. de 20261 de

RISCO NA GESTAÇÃO

Categoria D FDA. Evidência de risco fetal, pode ser necessário em situações graves

Adultos

1-3mg/kg/dia

1x/dia ou dividido

AlopurinolGRAVE

Inibe xantina oxidase - toxicidade

⛔ Reduzir dose de azatioprina em 75%

{"compativel":false,"observacao":"Evitar - metabólitos ativos no leite"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1	-Normal metabolism -Standard thiopurine dosing
Intermediate Metabolizer	1/3A, 1/3C	-Moderately reduced activity -Reduce thiopurine dose by 30-50% -Monitor for myelosuppression
Poor Metabolizer	3A/3A, 3C/3C, 3A/3C	-Severely reduced activity -Use 10% of standard dose OR avoid thiopurines -High risk of severe myelosuppression