Capecitabina

Pró-droga oral do 5-FU, convertida preferencialmente em células tumorais.

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RISCO NA GESTAÇÃO

Categoria D FDA. Evidência de risco fetal, pode ser necessário em situações graves

Adultos

1000-1250mg/m² VO 12/12h

Dias 1-14, ciclos de 21 dias

VarfarinaGRAVE

Aumenta INR significativamente

⛔ Monitorar INR frequentemente

{"compativel":false,"observacao":"Contraindicado"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1	-Normal metabolism -Standard 5-FU/capecitabine dosing
Poor Metabolizer	2A/1, 13/1	-Severely reduced metabolism -AVOID 5-FU/capecitabine OR reduce dose by 50% -High risk of severe toxicity
Intermediate Metabolizer	1/2A	-Moderately reduced activity -Reduce 5-FU/capecitabine dose by 50% -Monitor closely for toxicity