Diclofenaco sódico

AINE não seletivo potente. Inibe COX-1 e COX-2.

1 de dez. de 20241 de

1 cite1×

Gestação:Categoria CRisco não pode ser descartado, usar se benefício justificar

Este medicamento tem dados farmacogenéticos

Configure seus genótipos para ver alertas personalizados de dosagem.

INDICAÇÕES

Adultos

50mg 8/8h ou 75mg 12/12h

2-3x/dia

AnticoagulantesGRAVE

Risco de sangramento

⛔ Evitar

IECA/BRAGRAVE

IRA

⛔ Monitorar função renal

Usar por curto período

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1	-Normal diclofenac metabolism -Standard drug clearance
Poor Metabolizer	2/2, 3/3, 2/3	-Reduced diclofenac clearance (up to 3x AUC increase) -Increased drug exposure -Higher risk of GI bleeding, CV events, and hepatotoxicity
Intermediate Metabolizer	1/2, 1/3	-Moderately reduced clearance -May have 1.5-2x increased exposure

*Normal/Extensive Metabolizer: Standard dosing appropriate
*Normal/Extensive Metabolizer: Use lowest effective dose for shortest duration
*Poor Metabolizer: Consider 50% dose reduction
*Poor Metabolizer: Avoid prolonged use
*Poor Metabolizer: Consider alternative NSAID or non-NSAID analgesic
*Intermediate Metabolizer: Consider lower dose
*Intermediate Metabolizer: Monitor for GI and hepatic adverse effects