Metoprolol

Betabloqueador β1-seletivo. Reduz cronotropismo, inotropismo e consumo miocárdico de O2.

1 de fev. de 20261 de

Gestação:Categoria CRisco não pode ser descartado, usar se benefício justificar

INDICAÇÕES

Adultos

50-200mg

1-2x/dia

Adultos

12,5-25mg

Iniciar baixo, titular a cada 2 sem até 200mg/dia (succinato)

Verapamil/DiltiazemGRAVE

Bradicardia/BAV

⛔ Evitar, especialmente IV

ClonidinaGRAVE

Crise hipertensiva na retirada

⛔ Retirar BB antes da clonidina

{"compativel":true,"observacao":"Compatível, monitorar bradicardia no lactente"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1, 1/2, 2/2	-Normal drug metabolism -Standard dosing appropriate
Poor Metabolizer	4/4, 4/5, 5/5	-Reduced drug metabolism -Increased drug levels and toxicity risk -Consider dose reduction or alternative drug
Intermediate Metabolizer	1/4, 2/4	-Moderately reduced metabolism -May need dose adjustment
Ultra-rapid Metabolizer	1/1xN, 2/2xN	-Rapid drug metabolism -Reduced drug efficacy -May need increased dose or alternative drug

Phenotype

Variant

Clinical Implications

Normal/Extensive Metabolizer

*1/*1, *1/*2, *2/*2

Poor Metabolizer

*4/*4, *4/*5, *5/*5

Intermediate Metabolizer

*1/*4, *2/*4

Ultra-rapid Metabolizer

*1/*1xN, *2/*2xN