Ondansetrona

Antagonista seletivo do receptor 5-HT3 de serotonina.

1 de fev. de 20261 de

Gestação:Categoria BEstudos em animais não demonstraram risco, sem estudos em humanos

INDICAÇÕES

Adultos

8mg IV ou 16-24mg VO

30min antes QT, repetir 8/8h por 1-2 dias

Pediátrico

0,15mg/kg IV (máx 8mg)

Adultos

4mg IV lento

Fim da cirurgia

ApomorfinaGRAVE

Hipotensão grave

⛔ Contraindicado

Prolongadores QTGRAVE

Risco arritmia

⛔ Monitorar ECG

{"compativel":true,"observacao":"Provavelmente seguro"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1, 1/2, 2/2	-Normal drug metabolism -Standard dosing appropriate
Poor Metabolizer	4/4, 4/5, 5/5	-Reduced drug metabolism -Increased drug levels and toxicity risk -Consider dose reduction or alternative drug
Intermediate Metabolizer	1/4, 2/4	-Moderately reduced metabolism -May need dose adjustment
Ultra-rapid Metabolizer	1/1xN, 2/2xN	-Rapid drug metabolism -Reduced drug efficacy -May need increased dose or alternative drug