Rosuvastatina

Estatina de alta potência, mais hidrofílica. Menos metabolizada por CYP450.

1 de fev. de 20261 de

CONTRAINDICADO NA GESTAÇÃO

Categoria X FDA. Contraindicado na gestação - risco supera benefício

Adultos

20-40mg

1x/dia

CiclosporinaGRAVE

Miopatia

⛔ Dose máx 5mg

{"compativel":false,"observacao":"Contraindicado"}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1	-Normal function -Standard statin dosing
Intermediate Metabolizer	1/5, 1/15	-Reduced transport -Increased statin levels -Consider lower dose or alternative statin -Monitor for myopathy
Poor Metabolizer	5/5, 15/15	-Severely reduced transport -Significantly increased statin levels -Use lower dose or avoid simvastatin/atorvastatin -High risk of myopathy