Venlafaxina

Inibe recaptação de serotonina (doses baixas) e norepinefrina (doses altas >150mg). Efeito dose-dependente.

1 de fev. de 20261 de

Gestação:Categoria CRisco não pode ser descartado, usar se benefício justificar

INDICAÇÕES

Adultos

75mg XR

1x/dia com alimento

Adultos

75-225mg

1x/dia

IMAOGRAVE

Síndrome serotoninérgica

⛔ Intervalo 14 dias

TramadolGRAVE

Síndrome serotoninérgica + convulsões

⛔ Evitar

{"compativel":true,"observacao":"Com cautela. Preferir sertralina."}

1 gene with drug interactions

Pharmacogenomics testing may help personalize dosing for this medication. Results depend on patient's genetic profile.

Data source: PharmGKB

Phenotype	Variant	Clinical Implications
Normal/Extensive Metabolizer	1/1, 1/2, 2/2	-Normal drug metabolism -Standard dosing appropriate
Poor Metabolizer	4/4, 4/5, 5/5	-Reduced drug metabolism -Increased drug levels and toxicity risk -Consider dose reduction or alternative drug
Intermediate Metabolizer	1/4, 2/4	-Moderately reduced metabolism -May need dose adjustment
Ultra-rapid Metabolizer	1/1xN, 2/2xN	-Rapid drug metabolism -Reduced drug efficacy -May need increased dose or alternative drug